Building and maintaining the architecture and the function of the locomotor system

The axon-muscle connectome—defined as the precise and stereotyped wiring of motor neuron axon terminals to individual muscle fibers—is essential for coordinated motor function. In Drosophila, each motor neuron innervates a specific set of muscle fibers in a highly reproducible manner. This connectivity is established during development and is governed by distinct combinations of transcription factors expressed in MNs.

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Building and maintaining the architecture and the function of the locomotor system (PDF, 110 Ko)